insulin

Insulin in vials
December 8, 2016

Making human beta cells reproduce

A new method developed at Vanderbilt will speed the search for potential therapeutics for diabetes: compounds that stimulate the replication of insulin-producing beta cells.

By VUMC News and Communications
green traffic light
December 3, 2015

Microtubules act as cellular ‘rheostat’ to control insulin secretion

Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

By Leigh MacMillan
Insulin in vials
November 18, 2015

Fighting type 2 diabetes with FGF1

The growth factor FGF1 induces the growth of new insulin-producing beta cells and may help treat type 2 diabetes.

By VUMC News and Communications
Insulin in vials
September 10, 2015

Diabetes trial targets body’s ability to produce insulin

Kiersten Eaddy had long looked forward to her high school graduation day and joining her classmates to celebrate the accomplishment.

By VUMC News and Communications
August 20, 2015

New therapeutic target for diabetes

The factor FoxM1 increases the proliferation and function of insulin-producing beta cells, making it an attractive therapeutic target for diabetes.

By Leigh MacMillan
April 20, 2015

Boosting beta cells in diabetes

New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas.

By Leigh MacMillan
February 20, 2015

Tiny model of diabetes

Vanderbilt University researchers have created a zebrafish model of skeletal muscle insulin resistance that could help improve diabetes treatment.
By Bill Snyder
January 22, 2015

Beta cell link to fasting glucose

New findings explain why variation in a particular gene is the most important determinant of fasting blood glucose levels in humans.
By VUMC News and Communications
November 7, 2014

Overactive stress response in obesity

An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial.
By VUMC News and Communications
August 15, 2014

Weight regain after gastric bypass

Early weight regain after gastric bypass surgery does not reverse metabolic improvements, and the "hunger hormone" ghrelin might indicate who is susceptible to weight regain.
By Leigh MacMillan
July 17, 2014

Study examines therapeutic bacteria’s ability to prevent obesity

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered.
By Leigh MacMillan
June 12, 2014

Study tracks insulin’s risks as second-line diabetes medication

In an observational study by researchers at Vanderbilt University Medical Center, adults with type 2 diabetes who take insulin in addition to the recommended first-line drug therapy, metformin, had a 30 percent higher risk of heart attack, stroke or death when compared to similar patients who instead augment their metformin regimen with a sulfonylurea.
By Paul Govern
May 14, 2014

CaMKII enhances insulin secretion

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion.
By VUMC News and Communications
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