Vanderbilt University researchers have created a zebrafish model of skeletal muscle insulin resistance that could help improve diabetes treatment.

New findings explain why variation in a particular gene is the most important determinant of fasting blood glucose levels in humans.

An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial.

Early weight regain after gastric bypass surgery does not reverse metabolic improvements, and the "hunger hormone" ghrelin might indicate who is susceptible to weight regain.

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered.

In an observational study by researchers at Vanderbilt University Medical Center, adults with type 2 diabetes who take insulin in addition to the recommended first-line drug therapy, metformin, had a 30 percent higher risk of heart attack, stroke or death when compared to similar patients who instead augment their metformin regimen with a sulfonylurea.

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion.