NIGMS

July 12, 2021

Probing statin-associated diseases with genetics

Vanderbilt researchers used genetics tools and biobanks with linked electronic health records to explore the associations between statins and noncardiovascular diseases.

By Leigh MacMillan
July 8, 2021

Genetics of hydrocephalus

Fluid build-up in the brain — hydrocephalus — increases pressure and risk for brain damage; Vanderbilt researchers have now identified genes and signaling pathways associated with the condition.

By Leigh MacMillan
May 20, 2021

New clue to lung scarring

Vanderbilt neonatology team pinpoints signaling pathways involved in the progressive lung fibrosis that occurs in rare genetic diseases.

By Bill Snyder
April 15, 2021

Arrhythmia culprit: supertrafficking ion channel

Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.

By Leigh MacMillan
From left, Kimryn Rathmell, MD, PhD, Bradley Reinfeld, Matthew Madden and Jeffrey Rathmell, PhD, have discovered that immune cells — not cancer cells — are the major glucose consumers in the tumor microenvironment, upending a century-old observation.
April 7, 2021

Study revises understanding of cancer metabolism

Tumors consume glucose at high rates, but a team of Vanderbilt researchers has discovered that cancer cells themselves are not the culprit, upending models of cancer metabolism that have been developed and refined over the last 100 years.

By Leigh MacMillan
February 23, 2021

Calcification after severe injury

Vanderbilt researchers have linked bone-related complications of severely injured patients — findings that could help minimize these complications.

By Emily Stembridge
February 18, 2021

Gene variant and glucose metabolism

Genetic variation that impacts glucose- and insulin-related signaling affects responses to type 2 diabetes treatments and warrants further study.
By Leigh MacMillan
January 12, 2021

Mitochondrial stress and hypertension

Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential.
By Leigh MacMillan
January 7, 2021

Building a cohort, the easy way

An automated system using keyword searches can help identify candidates for clinical trials on adverse drug reactions.
By Paul Govern
November 17, 2020

A cohort for type 2 diabetes studies

A study group of more than 600,000 patients with type 2 diabetes, identified from electronic medical records in the PCORnet national research network, could be valuable for assessing the safety of type 2 diabetes drugs.
By Leigh MacMillan
September 17, 2020

Probing pathogen antibiotic resistance

Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics.
By Leigh MacMillan
September 3, 2020

Assembling cell power plant machinery

Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.
By Leigh MacMillan
August 20, 2020

A “torque” for tumor blood vessels

Vanderbilt scientists have discovered a new target for normalizing tumor blood vessels to improve cancer immunotherapies.
By Bill Snyder
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