NIGMS

P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.

Vanderbilt scientists led by Andrea Page-McCaw have discovered a new way to analyze repair of basement membranes — important structural and functional components of tissues.

Vanderbilt investigators have characterized how a new first-in-class antibacterial drug works, which will guide the development of additional compounds that overcome antibacterial resistance.

In a series of studies that volleyed between large databases and research in zebrafish, Vanderbilt investigators have discovered a link between vascular biology and eye disease.

Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.

Vanderbilt researchers led by Eric Skaar are probing the mechanisms bacteria use when faced with nutrient starvation — a host defense strategy called “nutritional immunity.”

A muscle relaxing-drug and inhibitors of the metabolic enzyme CYP1A2 interact to cause severely low blood pressure and should not be co-prescribed, Vanderbilt investigators caution.