NIH Archive — Page 27 of 93

Illustration of red blood cells interspersed with smaller spherical cells in a dark red bloodstream.
January 23, 2020

HDL-cholesterol and breast cancer risk

Genetic analyses suggest that high circulating HDL-cholesterol levels may increase breast cancer risk — a surprising finding since increased HDL-cholesterol is thought to be healthy.

By Leigh MacMillan
Portrait of Edwin Trevathan, MD, MPH, wearing a dark pinstriped jacket and white shirt against a brown background.
January 23, 2020

VIGH’s Trevathan appointed to NINDS Advisory Council

Edwin Trevathan, MD, MPH, director of the Vanderbilt Institute for Global Health, has been appointed to the Advisory Council for the National Institute for Neurological Diseases and Stroke (NINDS) of the National Institutes of Health.

By Holly Fletcher
Side-by-side fluorescent microscopy comparison: larger, regularly shaped healthy cartilage cells on the left and smaller, irregularly shaped cells in the CATIFA model on the right, labeled “Healthy Cartilage Cells” and “CATIFA model Cartilage Cells.”
January 13, 2020

Vanderbilt-led team discovers new genetic disease and defines underlying mechanism

An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms.

By Leigh MacMillan
Illustration of branching cream-colored blood vessels with blue and dark red channels, surrounded by green cell-like forms, small white microbes, and scattered particles on a reddish background.
January 13, 2020

Zinc uptake by a deadly pathogen

The increasingly antibiotic-resistant bacterium Acinetobacter baumannii requires zinc to cause infection, and Vanderbilt researchers have identified the zinc uptake system it uses.

By Leigh MacMillan
Illustration of a magnifying glass enlarging the porous internal structure of a bone, with a partial skeletal bone visible behind it.
January 10, 2020

Bone matrix changes during aging

Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis.

By Leigh MacMillan
Multi-panel molecular structure diagram showing a colored pore and prepore complex (a), with wireframe views of the pore (b) and prepore (c). Scale bars indicate 93 Å, 32 Å, and 98 Å.
January 10, 2020

Structural views of a C. diff toxin

D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.

By Leigh MacMillan