PNAS

January 31, 2019

Designing antibodies to fight the flu

Vanderbilt investigators said their work shows that computational design can improve the ability of naturally occurring antibodies to recognize different flu strains and may hasten the development of more effective flu therapies and vaccines.

By Bill Snyder
January 17, 2019

Signals from the “conveyor belt”

Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

By Bill Snyder
January 17, 2019

DNA’s on/off switch

DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

By Bill Snyder
August 30, 2018

Energetic gene switch

New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.

By Bill Snyder
August 16, 2018

Predictive models for gene regulation

Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.

By Bill Snyder
July 19, 2018

Fueling the MATE transporter

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.

By Sanjay Mishra
May 3, 2018

Understanding HDL structure

Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.
By Leigh MacMillan
March 8, 2018

Iron-sulfur “intersection”

Vanderbilt researchers have discovered an unanticipated link between sulfur and iron balance, pointing to a genetic basis for iron-deficiency anemia.
By Sanjay Mishra
February 22, 2018

Glaucoma study finds brain fights to preserve vision

A team of researchers, led by David Calkins, PhD, vice chair and director of Research at the Vanderbilt Eye Institute, has made a breakthrough discovery in the field of glaucoma showing new hopes for treatments to preserve vision.
By Jessica Pasley
January 12, 2018

BOLD view of white matter

Vanderbilt investigators have discovered that functional MRI detects neural activity in both gray and white matter in the brain, suggesting new ways to investigate diseases such as Alzheimer’s and multiple sclerosis.
By Bill Snyder
January 11, 2018

Lighting up iron levels

A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease.
By Leigh MacMillan
December 18, 2017

Brain lesions and criminal behavior linked to moral decision-making network

When brain lesions occur within the brain network responsible for morality and value-based decision-making, they can predispose a person toward criminal behavior, according to new research by Ryan Darby, MD, assistant professor of Neurology at Vanderbilt University Medical Center (VUMC).
By Tom Wilemon
August 4, 2017

An immune regulator of addiction

Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role.
By Sanjay Mishra