RNA

From left, Xiang Ye, PhD, Suba Rajendren, PhD, Antiana Richardson, and John Karijolich, PhD, are studying how the cancer-causing virus KSHV commandeers host gene expression and regulatory machinery.
April 20, 2023

Study details RNA editing in virus-infected cancer cells

Vanderbilt researchers detail the landscape of RNA editing — a form of RNA modification — in primary effusion lymphoma cells during Kaposi’s sarcoma-associated herpesvirus infection and identify an edited viral microRNA that is critical for infection.

By Leigh MacMillan
February 7, 2023

A new view of a cholesterol carrier

Vanderbilt researchers developed a novel method to measure small RNAs carried by HDL and demonstrated that these molecules circulate in greater concentrations than previously believed and are likely to contribute to communication between immune cells.

By Kelsey Pinckard 
November 15, 2021

Who’s who in the respiratory landscape

A metatranscriptomics method developed by Vanderbilt researchers simultaneously characterizes viruses, microbiome and host response in nasal swabs, opening opportunities to explore molecular interactions directly in clinical samples.

By Leigh MacMillan
September 30, 2021

Study shows how a protein coding gene confers breast cancer susceptibility during DNA transcription

Vanderbilt-Ingram Cancer Center research is providing new insights into how genetic variants convey breast cancer susceptibility by altering the transcription factor proteins that convert DNA strands into RNA.

By Tom Wilemon
The team studying the regulation of innate immune response includes (front row, from left) Yang Zhao, Antiana Richardson, (back row, from left) John Karijolich, PhD, Xiang Ye and William Dunker.
May 6, 2021

Study finds that regulatory protein prevents signaling that triggers cell death

A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.

By Leigh MacMillan
January 11, 2021

Microbial RNA and rheumatoid arthritis

Small RNAs — short stretches of genetic material — from microbes may be playing a role in rheumatoid arthritis and other autoimmune diseases.

By Leigh MacMillan
July 23, 2020

Cellular antiviral defenses

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.
By Leigh MacMillan
March 23, 2020

Cellular factor helps package flu genome

New insights on influenza genome packaging could guide strategies for interfering with the virus’s life cycle and ability to cause infection.
By Leigh MacMillan
October 1, 2019

Pua lands NIH Director’s New Innovator Award

Heather Pua, MD, PhD, one of 60 investigators to receive the 2019 NIH Director’s New Innovator Award, will explore a novel type of cell signaling by RNAs in allergic airway inflammation.
By Leigh MacMillan
August 26, 2019

VUMC investigators receive Keck Foundation award for novel atherosclerosis research

A team of researchers has received a $1 million grant from the W.M. Keck Foundation to explore a novel model of atherosclerosis development.
By Leigh MacMillan
February 14, 2019

Probing H. pylori cancer protein

Understanding how a bacterial protein that influences the risk of stomach cancer is produced could guide new strategies for treatment.
By Leigh MacMillan
December 13, 2018

RNA processing and antiviral immunity

John Karijolich and colleagues have discovered a link between cellular RNA processing and the innate cellular immune response to viral pathogens.
By Leigh MacMillan
October 25, 2018

Studying cellular deliveries

Vanderbilt researchers have characterized the functional transfer of long RNAs between colorectal cancer cells — a form of cell-cell communication that may contribute to cancer aggressiveness.
By VUMC News and Communications
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