Zhongming Zhao

July 15, 2015

Drug signaling networks

Vanderbilt investigators have developed a new algorithm to understand the networks of signaling molecules that control drug action.

By Leigh MacMillan
double helix
January 22, 2015

New data mining method reveals cancer-driving genes

Prospecting for genes that might be implicated in cancer, a Vanderbilt University Medical Center research team has struck pay dirt.

By Paul Govern
November 11, 2014

Protein “pockets” help ID cancer genes

Vanderbilt investigators have used a computational biology approach to uncover new cancer drivers and biomarkers of anticancer drug response.

By Bill Snyder
September 25, 2014

Bradfords’ strong support bolsters melanoma research

When something attacks you, you want to attack it back. That’s how Lillian “Tooty” Bradford views her late husband James “Jimmy” Bradford Jr.’s decision to make an initial gift to fund melanoma research at Vanderbilt-Ingram Cancer Center (VICC).

By Christina Echegaray
September 18, 2014

VU study reveals shared pathways in psychiatric disorders

Schizophrenia and bipolar disorder share common genetic underpinnings. Vanderbilt researchers combined high-resolution gene expression studies with gene association data to reveal signaling pathways linked to schizophrenia and bipolar disorder.

By Leigh MacMillan
August 5, 2014

Drug discovery clues in network map

Vanderbilt investigators have constructed a network map that could guide the development of new targeted cancer therapies.

By Bill Snyder
March 5, 2014

Web tool speeds pulmonary hypertension discovery

The pulmonary arterial hypertension knowledgebase (PAHKB), developed by Vanderbilt researchers, provides a useful tool for identifying PAH-related genes and signaling pathways relevant to pathogenesis.
By VUMC News and Communications
November 13, 2013

Molecular circuits in ovarian cancer

Vanderbilt researchers have used bioinformatics analysis of gene expression data to describe molecular “circuits” that drive ovarian cancer.
By Leigh MacMillan
September 30, 2013

Gene interactions and cavities

Vanderbilt researchers used existing genome-wide association study datasets to identify gene interactions that contribute to tooth decay.
By Leigh MacMillan
September 12, 2013

VU study identifies DNA changes in drug-resistant cancer cells

Vanderbilt investigators have combined next-generation sequencing technologies and bioinformatics analyses to screen for genome-wide genetic mutations associated with drug resistance in a series of lung cancer cell lines.
By Leigh MacMillan
August 9, 2012

Network approach yields glioblastoma clues

MicroRNA “regulatory networks” generated at Vanderbilt aid search for biomarkers and new drugs to treat glioblastoma, the most common and lethal primary brain tumor.
By Bill Snyder
July 26, 2012

Study finds mutation in melanoma sensitive to drug

An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to a specific drug therapy, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation.
By VUMC News and Communications
June 19, 2012

Gene database to aid disease research

A new catalog of human genetic data may help researchers uncover the genetic roots of disease and enable the ultimate realization of personalized medicine.
By Bill Snyder