Cancer

Mary Philip, MD, PhD, left, and Michael Rudloff, PhD, found that T cells become “exhausted” within hours of encountering a tumor, challenging existing ideas about how T cells become dysfunctional. (photo by Anthony Czelusniak)
August 3, 2023

Study finds hallmarks of T cell exhaustion within hours of tumor exposure

Vanderbilt researchers found that T cells become “exhausted” within hours of encountering a tumor, challenging existing ideas about how T cells become dysfunctional.

By Leigh MacMillan
July 26, 2023

International workgroup of geneticists issues CHEK2 guidelines

International workgroup issues additional guidance on how to manage patients who carry inherited CHEK2 gene mutations that put them at a higher risk for cancer.

By Tom Wilemon
July 25, 2023

Signaling pathways in liposarcomas

A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.

By Leigh MacMillan
Deneen Eastridge, left, recently traveled from Dallas to Nashville to meet Trina Hughes, the stem cell donor who gave her the gift of life 10 years ago. (photo by Erin O. Smith)
July 20, 2023

Stem cell recipient meets donor who saved her life 10 years ago

Each passing day is precious for Deneen Eastridge, but a decade is a priceless gift. The Dallas resident came to Nashville recently to meet Trina Hughes, the stem cell donor who gave her the gift of life 10 years ago.

By Tom Wilemon
July 7, 2023

Study reveals new clue to gastric cancer

Researchers at Vanderbilt University Medical Center have uncovered evidence of fibroblast cells’ direct involvement in the development of gastric cancer.

By Bill Snyder
June 29, 2023

Selenium signal found in colorectal cancer: study

An antioxidant transporter of the trace mineral selenium that protects against inflammatory bowel disease has the opposite effect in colorectal cancer, where it promotes tumor growth, researchers at Vanderbilt University Medical Center have reported.

By Bill Snyder
June 29, 2023

Study identifies key regulator of melanoma development

Vanderbilt investigators have revealed the mechanisms by which the chemokine receptor CXCR2, is associated with melanoma tumor formation and growth — a discovery that supports the continued development of drugs that inhibit the receptor’s activity.
By Tom Wilemon
June 21, 2023

Three Vanderbilt physicians named ASCO fellows

Three Vanderbilt-Ingram Cancer Center physicians were recently named fellows of the American Society of Clinical Oncology.
By Tom Wilemon
June 15, 2023

New treatment option for metastatic colorectal cancer prolongs survival

Research conducted at Vanderbilt points to a new therapy is on the horizon for patients with metastatic colorectal cancer who have run out of treatment options.
By Tom Wilemon
June 15, 2023

Early-onset CRC germline genetic differences identified by race, ethnicity

A Vanderbilt study that delved into genetic predisposition for early-onset colorectal cancer by race and ethnicity has identified differing germline risk variants.
By Tom Wilemon
June 8, 2023

An image of cancer treatment response

An MRI method developed by Vanderbilt researchers uses imaging data to derive cell size and could be added to clinical practice for better monitoring of breast cancer treatment response.
By Sarah E. Glass
June 8, 2023

Enhanced treatment helps fast nicotine metabolizers quit smoking

A study from Vanderbilt researchers has found that enhanced treatment support can help smokers who have more difficulty quitting because they are fast metabolizers of nicotine.
By Tom Wilemon
June 5, 2023

Study discovers that tumor mutation burden predicts survival outcome

The expected course of a patient's cancer prognosis has traditionally been judged by its type, stage and microscopic aggressiveness, but patients with the same presentation can still have widely divergent outcomes. Researchers from Vanderbilt-Ingram Cancer Center have discovered that differences in tumor mutation burden are a major reason for this divergence.
By Tom Wilemon
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