Cell Reports (journal)

January 21, 2021

WIN for blocking cancer growth

William Tansey and colleagues identified proteins that interact with the cancer drug target WDR5 and are important for cancer cell growth.

By Sarah E. Glass
September 17, 2020

Probing pathogen antibiotic resistance

Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics.

By Leigh MacMillan
September 3, 2020

New clue to Alzheimer’s disease

Combining studies of genetically diverse mouse populations and human data led to the identification of a gene associated with cognitive decline and brain changes in Alzheimer’s disease.

By Bill Snyder
August 6, 2020

The importance of estrogen cycles

Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer.

By Sarah E. Glass
July 9, 2020

New study supports remdesivir as COVID-19 treatment

This week researchers at Vanderbilt University Medical Center (VUMC), the University of North Carolina at Chapel Hill and Gilead Sciences reported that remdesivir potently inhibited SARS-CoV-2, the virus which causes COVID-19, in human lung cell cultures and that it improved lung function in mice infected with the virus.

By Bill Snyder
June 18, 2020

Probing DNA damage repair

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

By Leigh MacMillan
June 18, 2020

Studying cells in reduced dimensions

Vanderbilt cell biologists have developed an unbiased, quantitative framework for evaluating single-cell data.
By Bill Snyder
April 16, 2020

‘Tuning’ cell shape for division

Dylan Burnette and colleagues have discovered that two forms of the molecular motor protein myosin have distinct roles in regulating cell shape during cell division.
By Leigh MacMillan
October 21, 2019

Completing DNA synthesis

James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.
By Leigh MacMillan
October 3, 2019

A catalog of DNA replication proteins

Vanderbilt scientists have identified 593 proteins that are enriched at sites of DNA duplication and chromatin packaging of newly synthesized DNA.
By Leigh MacMillan
September 5, 2019

Zebrafish aid effort to regenerate damaged retinas

According to a new study, the tiny zebrafish may hold the secret to regenerating damaged retinas in humans.
By Bill Snyder
August 27, 2019

A “rheostat” for cancer signals

Jason MacGurn and colleagues have characterized a “rheostat” that sets WNT pathway signaling in breast cancer cells.
By Sanjay Mishra
April 11, 2019

How bugs overcome host defenses

Vanderbilt researchers led by Eric Skaar are probing the mechanisms bacteria use when faced with nutrient starvation — a host defense strategy called “nutritional immunity.”
By Leigh MacMillan
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