The therapy, haploidentical bone marrow transplant with thiotepa and posttransplant cyclophosphamide, is as safe and more affordable than the recently FDA-approved myeloablative gene therapy and gene editing treatments.

Preoxygenation is the administration of supplemental oxygen prior to the start of a procedure to increase the content of oxygen in the lung and decrease the risk of hypoxemia

In 2008 at VUMC there were a group of doctors trying something unheard of on a handful of patients who signed up for their study. Half would receive deep brain stimulation (DBS) surgery in attempt to slow the progression of their early-stage Parkinson’s disease, and the others would not.

The funds will help launch a clinical trial in the U.S. with one of the therapies and compare it with another therapy from an ongoing clinical trial in Japan.

Participants may be able to join this study if they have Down syndrome, are between 35 and 50 years old and have a study partner willing to attend all study visits.

Findings from NIH-supported clinical trial suggest that intravenous acetaminophen has the greatest benefit in the sickest patients.

Developed in a region with the world’s highest HIV prevalence, this study design and intervention has the potential to impact testing uptake among a “hidden population” by mobilizing trained healers, who vastly outnumber allopathic care providers in South Africa.