Department of Pediatrics

Rett syndrome drug studied at Vanderbilt approved for patients

The first drug to treat the symptoms of Rett syndrome was recently approved, following a Nature Medicine study publishing results from the pivotal phase 3 LAVENDER study led by investigators from Vanderbilt University Medical Center to evaluate efficacy and safety of trofinetide.

In this 3D projected still image from a precision cut lung slice, alveolar epithelial cells are labeled green. All other cells are seen in purple.

Vanderbilt researchers envision the potential to grow new lungs

Using a four-dimensional microscope that allows them to watch a tissue putting itself together, researchers at Vanderbilt University Medical Center have achieved a rare feat in science — they have shattered a long-standing dogma about how the lung develops.

Tennessee Pediatric Neurocritical Care Collaboration holds inaugural conference

Monroe Carell Jr. Children’s Hospital at Vanderbilt recently hosted the first statewide conference of the Tennessee Pediatric Neurocritical Care Collaboration.

Persistent inflammatory state found in half of pediatric sepsis deaths: study

New research shows that about half of pediatric patients who died of sepsis over the past 20 years at Vanderbilt University Medical Center had evidence of an inflammatory state called persistent inflammation, immunosuppression and catabolism syndrome.

Mosaicism and genetic disease

Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.

Vanderbilt’s pediatric neurocritical care team treated patient Will Terry after he suffered a traumatic brain injury when he flipped over the handlebars of a kick scooter.

Neurocritical care team helps boy survive severe brain injury

Vanderbilt’s pediatric neurocritical care team combines experts from different areas of pediatric medicine to care for each child according to individual needs to maximize that child’s quality recovery.

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