James Crowe Archive — Page 2 of 13

(iStock)
August 13, 2024

VUMC, DOD join forces for a hantavirus antibody ‘sprint’

VUMC’s antibody collaboration with the DOD goes back to 2018, when the medical center signed a five-year cooperative agreement with the U.S. Defense Advanced Research Projects Agency to develop protective treatments that can be rushed to health care providers within weeks after a viral outbreak.

3D rendering of an enterovirus D68 particle covered by red, yellow, and blue viral proteins and orange and purple antibodies, overlaid on a colorized electron micrograph showing green virus particles.
June 28, 2024

Antibody trial launched to address enterovirus threat

Enterovirus D68 has caused an increasing number of infections during the past decade and is associated with acute flaccid myelitis, a polio-like condition that mostly affects children and causes sudden weakness and paralysis.

Illustration of a spherical parainfluenza virus particle with a textured orange surface and numerous irregular multicolored spike-like structures, alongside a blurred particle in the foreground.
June 12, 2024

Scientists find antibodies that block parainfluenza virus infection

The antibodies may have clinical benefit as antiviral drugs to treat potentially life-threatening infections in elderly and immunosuppressed patients.

3D molecular rendering of an influenza B virus particle between two textured purple cell surfaces, with a red neuraminidase protein bound by several blue and pale-colored antibody molecules; an orange hemagglutinin structure spans the lower portion.
May 31, 2024

Antibodies may aid effort to fight influenza B: study

The findings reported in the journal Immunity support the development of a monoclonal antibody for prevention and treatment of influenza B — and will help guide efforts to develop a universal influenza vaccine.

3D medical illustration of a syringe dispensing small blue and green Y-shaped antibody forms among larger blue and green molecular structures against a red background.
May 8, 2024

Supercomputing redesign of a COVID monoclonal antibody

The approach, which combines high-performance computing, simulation, machine learning and experimental validation, will help keep antibody drugs up to date in the future against highly variable viruses.

Portrait of Katherine Van Schaik smiling in a dark blazer and light top, seated in front of bookshelves.
January 16, 2024

Following the clues through time: Old mummies, old bones and old teeth lead to new insight into disease for Katherine Van Schaik

Radiology fellow moves from present-day patients to historical artifacts to understand health and illness