oxidative damage

March 7, 2024

Study details metabolism of biomarkers for oxidative stress

Factors other than oxidative stress can modify the levels of biomarkers called isoprostanes that are commonly used in both experimental and clinical research, suggesting that additional standards need to be developed.

By Leigh MacMillan
January 6, 2023

MicroRNAs linked to lipid damage

VUMC researchers have linked microRNAs with systemic lipid peroxidation, a discovery that could point to new therapeutic targets for a variety of diseases.

By Sarah E. Glass
October 20, 2022

New target for lung fibrosis

Blocking thromboxane-prostanoid receptor signaling protected animals from lung fibrosis in preclinical models, suggesting a new treatment for IPF — a chronic, progressive lung disorder that often kills within 3-5 years of diagnosis.

By Leigh MacMillan
doctor checking patient's blood pressure
January 12, 2021

Mitochondrial stress and hypertension

Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential.

By Leigh MacMillan
August 6, 2020

The importance of estrogen cycles

Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer.

By Sarah E. Glass
January 27, 2020

A new contributor to atherosclerosis

Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.

By Leigh MacMillan
February 22, 2018

Mitochondrial mutations and disease

New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state.
By Sanjay Mishra
February 12, 2018

Protecting transplanted lungs

Acetaminophen may offer a simple treatment to prevent tissue injury following lung transplant, Vanderbilt researchers have discovered.
By Leigh MacMillan
October 20, 2016

Study finds natural compound extends lifespan of worms

A compound found in buckwheat seeds extends the lifespan of worms, Vanderbilt investigators have discovered.
By Leigh MacMillan
May 9, 2014

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.
By VUMC News and Communications
August 14, 2013

Oxidative stress in autism

A biomarker for oxidative stress is elevated in patients with both autism spectrum disorder and gastrointestinal dysfunction, suggesting opportunities for individualized approaches to clinical care.
By Bill Snyder
March 28, 2013

Acetaminophen: protective in sepsis?

In critically ill patients with sepsis, plasma hemoglobin may be a new indicator of disease severity – and a potential target for treatment with acetaminophen.
By Leigh MacMillan
September 11, 2012

Enzyme counters stomach acid attack

Dysfunction or loss of an “antioxidant” enzyme may lead to higher risk for esophageal cancer in patients with gastric reflux disease.
By VUMC News and Communications
1 2