Proceedings of the National Academy of Sciences (PNAS) (journal)

Designing antibodies to fight the flu

Vanderbilt investigators said their work shows that computational design can improve the ability of naturally occurring antibodies to recognize different flu strains and may hasten the development of more effective flu therapies and vaccines.

Signals from the “conveyor belt”

Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

DNA’s on/off switch

DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

New study looks at brain networks involved in free will

Using lesion network mapping, a recently developed technique for analyzing how the brain works, Ryan Darby, MD, assistant professor of Neurology at Vanderbilt, studied free will perception related to movement decisions.

Energetic gene switch

New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.

Predictive models for gene regulation

Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.

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