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schizophrenia Archives

Brain circuits in schizophrenia

Sep. 20, 2021—Vanderbilt psychiatrists are probing brain circuit hyperactivity implicated in schizophrenia, with the idea that normalizing the hyperactivity may improve cognitive processes.

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White matter and schizophrenia

Sep. 2, 2021—Patients with schizophrenia have functional changes in the white matter of the brain, Vanderbilt researchers have discovered, which may contribute to impaired working memory and processing speed.

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Pinpointing brain changes in psychosis

Oct. 1, 2020—Specific regions of the thalamus — a central brain region — are smaller in adults with psychotic disorders and youth at risk for psychotic disorders and are associated with cognitive impairment.

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A connection to schizophrenia

Jun. 23, 2020—The insula, a small region of the brain involved in diverse brain functions had widespread dysconnectivity in schizophrenia, Vanderbilt researchers found.

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Relational memory in early psychosis

Sep. 10, 2019—Studies of relational memory function may reveal novel mechanisms for therapeutic intervention for patients in the early stages of psychosis.

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Working memory in psychotic disorders

Jul. 11, 2019—Functional MRI studies have revealed that targeting activation of certain brain regions may improve working memory and cognition in psychotic disorders.

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Early detection of schizophrenia

Jun. 24, 2019—Inhibited temperament — a tendency to respond to novelty with wariness, fear or caution — may be a risk factor for schizophrenia that could be targeted for preventative interventions.

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$10 million gift bolsters psychosis research efforts

Jun. 13, 2019—A $10 million endowed gift will fund translational research, support clinical programs and create an endowed chair within the Department of Psychiatry.

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Immune ‘pruning’ in schizophrenia

Apr. 25, 2019—Ariel Deutch and colleagues have discovered that overactive brain immune cells during adolescence may contribute to schizophrenia.

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Researchers find high-risk genes for schizophrenia

Apr. 18, 2019—Using a unique computational framework they developed, a team of scientist cyber-sleuths in the Vanderbilt University Department of Molecular Physiology and Biophysics and the Vanderbilt Genetics Institute (VGI) has identified 104 high-risk genes for schizophrenia.

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Treatment resistance of mental disorders studied

Mar. 28, 2019—With the aid of a four-year, $3.4 million grant from the National Institute of Mental Health, researchers at Vanderbilt University Medical Center and Massachusetts General Hospital (MGH) will apply new techniques to investigate treatment resistance of two devastating mental disorders — major depressive disorder, which befalls 15 percent of people at some point in their lives, and schizophrenia, which affects approximately 1 percent.

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Cytokine-cognition connection

Oct. 1, 2018—Targeting the immune system may provide a new avenue for therapeutic intervention in psychiatric diseases characterized by motivational and cognitive deficits.

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