Science Translational Medicine (journal)

May 10, 2022

Resistance to COVID-19 drug detected in lab study

Vanderbilt research shows that the virus that causes COVID-19 can develop partial resistance to the antiviral drug remdesivir during infection of cultured cells in the laboratory by more than one mechanism.  

By Bill Snyder
Research by Dane Chetkovich, MD, PhD, right, Ye Han, PhD, and colleagues on how antidepressants work points to possible new targets for drug development.
December 1, 2021

Study provides new insight into how antidepressant drugs work

A study by Vanderbilt researchers sheds light on how current antidepressant drugs work and suggests a new drug target in depression.

By Paul Govern
April 6, 2020

VUMC team aids development of potential antiviral drug for COVID-19

Researchers at Vanderbilt University Medical Center are playing a key role in the development of a potential new antiviral drug to treat COVID-19.

By Bill Snyder
March 12, 2020

Triple-negative breast cancer drug therapy shows promise

Researchers from Vanderbilt-Ingram Cancer Center (VICC) discovered a role for MYCN in triple-negative breast cancer (TNBC), a particularly aggressive form of the disease, and identified a potential intervention for further clinical investigation.

By Tom Wilemon
August 15, 2019

Potential second-line melanoma treatment identified

A study led by Anna Vilgelm, MD, PhD, and Ann Richmond, PhD, has identified a possible second-line treatment for melanoma patients.

By Tom Wilemon
January 31, 2019

New target for chronic kidney disease

Preventing the formation of secretory structures that promote scarring in the kidney could offer new therapeutic options for a disease that affects millions of people worldwide.

By Leigh MacMillan
March 15, 2018

New imaging approach offers unprecedented views of staph infection

A new integrated imaging approach makes it possible to probe the molecules involved in invasive infections and can be broadly applied to any health or disease state.
By Leigh MacMillan
August 24, 2017

Drug discovery efforts may lead to new Rett syndrome treatments

Vanderbilt University research-ers have relieved symptoms of Rett syndrome in a mouse model with a small molecule that works like the dimmer switch in an electrical circuit.
By Bill Snyder
August 9, 2017

Breast Cancer Genomic Profiling Reveals Clues to Treatment Resistance

Thanks to advances in treatment, the relative five-year survival rate from all combined subtypes of breast cancer now exceeds 90 percent and yet the disease remains the third leading cause of cancer deaths in the United States after lung and colorectal cancers.
By Bill Snyder
June 29, 2017

Team investigates antiviral that inhibits SARS, MERS

A new antiviral drug candidate inhibits a broad range of coronaviruses, including the SARS and MERS coronaviruses, a multi-institutional team of investigators reports this week in Science Translational Medicine.
By Leigh MacMillan
May 10, 2017

Scientists create unique disease ‘catalog’ linked to immune system gene variations

A study led by researchers at Vanderbilt University Medical Center (VUMC) and the University of Arizona College of Pharmacy has generated the first comprehensive catalog of diseases in a single population associated with variations in HLA genes that regulate the body's immune system.
By Bill Snyder
April 21, 2016

Study explores how some breast cancers resist treatment

A targeted therapy for triple-negative breast cancer (TNBC), the most aggressive form of breast cancer, has shown potential promise in a recently published study. TNBC is the only type of breast cancer for which there are no currently approved targeted therapies.
By VUMC News and Communications
June 18, 2015

New nanoparticle enhances success rate of coronary artery bypass grafts

A team of Vanderbilt University Medical Center surgeons and biomedical engineers has developed a nanoparticle delivery system that may significantly improve the success rate of coronary artery bypass grafts.
By Bill Snyder
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