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Mosaicism and genetic disease

Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.

Vanderbilt’s pediatric neurocritical care team treated patient Will Terry after he suffered a traumatic brain injury when he flipped over the handlebars of a kick scooter. (photo by Susan Urmy)

Neurocritical care team helps boy survive severe brain injury

Vanderbilt’s pediatric neurocritical care team combines experts from different areas of pediatric medicine to care for each child according to individual needs to maximize that child’s quality recovery.

Research assistant Mahsa Majedi loads reagent used in DNA sample preparation in the genomics lab. She is part of a team of more than a dozen people at VUMC who are “sprinting” to develop — within 90 days — an antibody-based treatment to stop the spread of the Zika virus.

VUMC, Oxford team develops ‘blueprint’ to block lethal virus

Researchers at Vanderbilt University Medical Center and the University of Oxford have determined how a human monoclonal antibody isolated at Vanderbilt in 2021 can prevent infection by the potentially lethal Sin Nombre virus.

Montenovo named chief of Hepatobiliary Surgery and Liver Transplantation

Martin Montenovo, MD, has been named chief of Vanderbilt’s Division of Hepatobiliary Surgery and Liver Transplantation in the Department of Surgery.

NIH grant boosts international TB research consortium

A new grant will help support Vanderbilt’s RePORT Brazil, one of an international consortium’s six regional tuberculosis research programs.

A Vanderbilt study shows that reducing consumption of simple sugars helped improve gastroesophageal reflux disease.

Maternal diet influences postnatal diabetes risk

Studies in a primate animal model suggest that islet hyperfunction — which in humans is associated with increased fat mass and Type 2 diabetes — is programmed in offspring by a maternal Western-style diet during pregnancy.

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