Research Archive — Page 41 of 133

May 22, 2023

Neurofluid flow and Alzheimer’s disease

Vanderbilt researchers used novel MRI methods to noninvasively quantify measures of neurofluid circulation and found that hypertrophy of a site of cerebrospinal fluid egress may be related to amyloid-beta retention in Alzheimer’s disease.

skin cross section
May 18, 2023

A critical skin enzyme

Detailed studies of the enzymatic properties of PNPLA1 support the requirement for this protein in skin barrier formation.

May 18, 2023

Billing codes aid lupus diagnosis

Vanderbilt researchers used billing codes in electronic health records to develop a “phenotype risk score” that identified established and undiagnosed people with lupus.

From left are Kathy Gould, PhD, Vanderbilt Prize recipient Ruth Lehmann, PhD, Vanderbilt Prize Student Scholar Catherine Shelton and John Kuriyan, PhD.
May 18, 2023

Vanderbilt Prize lecture highlights diversity, mentoring

Ruth Lehmann, PhD, director of the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, delivered last week’s Vanderbilt Prize Discovery Lecture.

May 18, 2023

New view of mutations informs disease risk, treatment response

A transcontinental research effort led by scientists from Vanderbilt University Medical Center and the University of Michigan has upended some long-standing assumptions about mutations — how often they occur, what causes them and what they do.

May 11, 2023

Genomic analysis of SCLC tumors reveals subtypes, offers cues toward personalized treatments

The largest genomic analysis ever conducted of small cell lung cancer tumors (SCLC) has identified genetic subtypes and provided insights into the mechanisms of this aggressive and deadly cancer.