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Author: Leigh MacMillan

‘Detangler’ binds, bends and cuts DNA

Mar. 2, 2012—New details on the DNA-cutting activity of topoisomerase II, a target of anti-cancer drugs, could lead to better chemotherapeutic agents.

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Stem cells take heart

Feb. 20, 2012—Signaling pathway discoveries suggest ways to induce stem cells to become cardiac muscle cells, which could be useful for regenerating damaged heart muscle.

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Memory intact in early psychosis

Feb. 16, 2012—Brain deficits are not present in the early stages of schizophrenia, suggesting it may be possible to delay or prevent the development of brain abnormalities.

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Matchmaker for clinical studies

Feb. 8, 2012—ResearchMatch.org is a web-based registry that is connecting participants and researchers for clinical studies.

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Tool finds connections in genome data

Feb. 8, 2012—A new analytical tool points to genes that act together to increase disease risk.

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Alcohol’s molecular mediators

Jan. 23, 2012—Therapeutic agents focusing on the brain region involved in stress-induced relapse may be effective in preventing relapse in patients with alcohol use disorders.

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Studies shed new light on how nitric oxide is produced

Jan. 20, 2012—The discovery of a previously unrecognized and pivotal role of enzyme ASL in nitric oxide production could potentially lead to new therapies for babies with pulmonary hypertension.

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Pumping up the pancreas in pregnancy

Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.

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Fishing for heart attack repair tools

Jan. 5, 2012—Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool: zebrafish. The researchers visually screened...

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Clues to flattened faces

Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...

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Clues to skeletal form in ‘feelgood’ fish

Dec. 16, 2011—Ela Knapik, associate professor of medicine, and colleagues are using zebrafish to explore the molecular and cellular mechanisms that cause birth defects of the face and skeleton.

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Move out, cholesterol

Dec. 8, 2011—Compounds developed at Vanderbilt could offer a whole new way to treat atherosclerosis.

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Recent Stories from VUMC News and Communications Publications

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer.  Don’t hesitate. Do it.

Momentum

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer. Don’t hesitate. Do it.

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

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