cancer

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August 26, 2019

Cancer susceptibility genes

Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.

By Leigh MacMillan
August 8, 2019

New window on fibrosis

A previously unrecognized role for a cell surface receptor may open new therapeutic options for the treatment of fibrotic diseases.

By Bill Snyder
David Cortez, PhD, left, Petria Thompson, Katherine Amidon, Brandt Eichman, PhD, and colleagues are studying how a DNA repair pathway protein shields sites of damage to avoid mutations.
July 25, 2019

Team’s study reveals details of new DNA repair pathway

Investigators have discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity.

By Leigh MacMillan
June 6, 2019

Mouth microbes and colorectal cancer

Microbial species in the mouth could be playing a role in colorectal cancer development, according to new research from epidemiologists at VUMC.

By Leigh MacMillan
May 29, 2019

Study details regulation of a multi-drug transporter

P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.

By Leigh MacMillan
May 15, 2019

Protecting the skin from damaging sun rays is as easy as “slip, slop, slap, slide and shade”

By Jessica Pasley
May 3, 2019

Researchers putting the brakes on lethal childhood cancer

Malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers. Although rare — about 20 to 25 new cases are diagnosed annually in the United States — there is no standard effective treatment for the disease, which is driven by loss of an anti-cancer protein called SNF5. The chances are very small that a child will survive a year after MRT diagnosis.
By Bill Snyder
March 28, 2019

Cancer’s SOS

Stephen Fesik and colleagues are advancing cancer drug discovery with the characterization of small molecules that modulate RAS, an important target for anti-cancer therapies.
By Sanjay Mishra
March 14, 2019

Correctly copying DNA

A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.
By Sanjay Mishra
February 14, 2019

The yin and yang of cell signaling

Larry Marnett and colleagues have explored the role of two enzymes in metabolizing molecules associated with cell proliferation, inflammatory processes and neurological diseases.
By Sanjay Mishra
January 31, 2019

Grant supports novel imaging initiative to enhance cancer care

A Vanderbilt initiative to develop predictive imaging technologies that clinicians can use to better match patients with personalized care has received National Cancer Institute (NCI) funding.
By Tom Wilemon
January 23, 2019

Major grant to bolster research on inflammation-related cancers

Cancer Research UK has awarded a 20-million-pound grant (about $25 million U.S.) to a team of international investigators, including Vanderbilt’s James Goldenring, MD, PhD, to study inflammation-related cancers.
By Tom Wilemon
January 7, 2019

GE Healthcare, Vanderbilt University Medical Center partner for safer, more precise immunotherapy cancer treatment

GE Healthcare and Vanderbilt University Medical Center (VUMC) today announced a five-year partnership to enable safer and more precise cancer immunotherapies.
By VUMC News and Communications
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