Malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers. Although rare — about 20 to 25 new cases are diagnosed annually in the United States — there is no standard effective treatment for the disease, which is driven by loss of an anti-cancer protein called SNF5. The chances are very small that a child will survive a year after MRT diagnosis.

New discoveries by Jason MacGurn and colleagues further understanding of the complex machinery that cells use take up substances from outside the cell.

Ruth Lehmann, PhD, center, a world-renowned expert on the biology of germ cells, delivered last week’s Flexner Discovery Lecture.

Ruth Lehmann, PhD, a world-renowned expert on the biology of germ cells, which generate eggs and sperm, will deliver the next Flexner Discovery Lecture on Thursday, March 21.

Stephen Hann, PhD, professor of Cell and Developmental Biology, died Feb. 27. He was 67.

Matthew Tyska and colleagues have found that an adhesion protein plays a key role in building the intestinal brush border that is essential for absorbing nutrients.

Preventing the formation of secretory structures that promote scarring in the kidney could offer new therapeutic options for a disease that affects millions of people worldwide.