The modular architecture of small heat-shock proteins contributes to the ability of these proteins to aid cells in responding to stress.

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.

Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

A new protein structure may guide the development of Alzheimer's therapeutics.

A detailed structural and functional analysis of the yeast protein that is the main target of antifungal drugs will help direct efforts to develop better treatments.

New structural findings reveal how "gatekeeper" proteins participate in the secretion systems bacteria use to infect host cells.

New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants.