Cancer

Obesity-cancer connection discovery suggests strategies for improving immunotherapy 

The study reported in the journal Nature provides a mechanistic explanation for the “obesity paradox” — that obesity can contribute to cancer progression but also improve response to immunotherapy.

Brooke Emerling, PhD, and Raymond Blind, PhD (seated, in foreground) at a 2023 scientific symposium they organized. Standing next to Blind is Hua Ya, PhD, from the City of Hope Comprehensive Cancer Center. Behind him in the light blue shirt is Emilio Hirsch, PhD, from the University of Torino, Italy.

Discovery raises hopes for new cancer therapy

The study connected the Hippo signaling pathway to phosphoinositides, a particular type of lipid, or fat molecule, which regulates cell functions that are critical in cancer, obesity and diabetes.

Vanderbilt-Ingram Cancer Center’s clinicians will staff the Cancer Center at Cookeville Regional Medical Center

Through this agreement Vanderbilt-Ingram Cancer Center’s medical oncologists, radiation oncologists and advanced practice nurses will be Cookeville Regional’s exclusive providers of cancer services.

Eunyoung Choi, PhD, and James Goldenring, MD, PhD. (photo by Erin O. Smith)

Grant funds research for therapies to prevent stomach cancer

The funds will help launch a clinical trial in the U.S. with one of the therapies and compare it with another therapy from an ongoing clinical trial in Japan.

Graduate student Taralynn Mack, left, pipettes a sample while Alexander Bick, MD, graduate student Hannah Poisner, and Celestine Wanjalla, MD, PhD, look on.

Research raises hope for treating potentially lethal blood condition

Roughly 1 in 10 people over age 70 will develop CHIP, an explosive, clonal growth of abnormal blood cells that increases risk of blood cancers and death from cardiovascular, lung and liver disease.

Galen Perdikis, MD, left, and G. Patrick Maxwell, MD.

Dedication to advancing breast reconstruction surgery for patients links Perdikis, Maxwell

Perdikis now holds the recently established G. Patrick Maxwell, M.D. Chair of the Department of Plastic Surgery at Vanderbilt University Medical Center.

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