Department of Medicine

Research by Robert Coffey, MD, left, Dennis Jeppesen, PhD, and colleagues has revealed a new way cells shed DNA into the bloodstream.
April 11, 2019

Discovery aids search for cancer biomarkers

A report by researchers at Vanderbilt University Medical Center has shattered conventional wisdom about how cells, including cancer cells, shed DNA into the bloodstream: they don’t do it by packaging the genetic material in tiny vesicles called exosomes.

By Bill Snyder
From left, Benjamin Brown, Christine Lovly, MD, PhD, Yun-Kai Zhang, PhD, Jens Meiler, PhD, and colleagues are exploring new ways to understand resistance to targeted cancer therapy drugs.
April 11, 2019

Study reframes approach to targeted therapy resistance

When a tumor mutates and develops resistance to a targeted therapy, researchers often focus on the acquisition of new mutations within the drug target as they seek an alternative treatment, but a team of Vanderbilt scientists has shown this may not be sufficient.

By Tom Wilemon
April 4, 2019

Harvard’s Gaziano set for April 11 clinical pharmacology lecture

J. Michael Gaziano, MD, MPH, an internationally recognized chronic disease epidemiologist, will deliver the 15th annual Grant R. Wilkinson Distinguished Lectureship in Clinical Pharmacology on Thursday, April 11.

By Leigh MacMillan
Speakers at the inaugural SCRIPS Spring Symposium (Supporting Careers in Research for Interventional Physicians and Surgeons) last week were, from left, Kelle Moley, MD, senior vice president and chief scientific officer of the March of Dimes; 2018 SCRIPS Scholars Yash Choksi, MD, and Akshitkumar Mistry, MD; and Anil Rustgi, MD, the T. Grier Miller Professor of Medicine and Genetics at the University of Pennsylvania’s Perelman School of Medicine and incoming director of the Herbert Irving Comprehensive Cancer Center in New York. The SCRIPS program is supported by the Burroughs Wellcome Fund.
March 28, 2019

SCRIPS Symposium

Speakers at the inaugural SCRIPS Spring Symposium (Supporting Careers in Research for Interventional Physicians and Surgeons) last week were, from left, Kelle Moley, MD, senior vice president and chief scientific officer of the March of Dimes; 2018 SCRIPS Scholars Yash Choksi, MD, and Akshitkumar Mistry, MD; and Anil Rustgi, MD.
March 28, 2019

Cancer prevention drug also disables H. pylori bacterium

A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.

By Leigh MacMillan
Longtime colleagues and friends Curt Thorne, left, and Terry Burke enjoyed sailing together.
March 28, 2019

Bladder cancer research fund honors mentor’s lasting influence

The Terry Burke Fund for Bladder Cancer Research at Vanderbilt-Ingram Cancer Center is supporting a range of discovery research aimed at improving outcomes for bladder cancer patients, and it is helping train the next generation of bladder cancer physician-scientists.

By Leigh MacMillan
March 14, 2019

Cancer Center Ambassadors surpass $1 million in grants

Vanderbilt-Ingram Cancer Center Ambassadors surpassed the $1 million mark with the awarding of the group’s latest research grants.
By Tom Wilemon
February 28, 2019

Achilles’ heel for kidney cancer

The discovery that kidney cells with mutations in a certain gene are sensitive to therapies called PI3K inhibitors opens new opportunities for applying precision medicine to cancer treatment.
By VUMC News and Communications
February 28, 2019

Protein loss promotes cell migration

The protein kinase STK17A plays a novel role in epithelial cells and its loss may contribute to colorectal cancer invasion and metastasis, Vanderbilt researchers report.
By Leigh MacMillan
February 28, 2019

Gene identified that increases risk of antibiotic reaction

Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin.
By Bill Snyder
February 28, 2019

Investigators map genomic landscape of very rare cancer

A team of Vanderbilt researchers mapped out the genomic landscape of a metastatic malignant proliferating tricholemmal tumor and identified a targeted treatment for this very rare cancer.
By Tom Wilemon
February 18, 2019

VUMC study finds helping patients breathe during intubation prevents life-threatening complications

Thousands of Americans die each year during a dangerous two-minute procedure to insert a breathing tube. Now a Vanderbilt University Medical Center (VUMC) study in the New England Journal of Medicine (NEJM) is showing that using bag-mask ventilation, squeezing air from a bag into the mouth for 60 seconds to help patients’ breathing, improves outcomes and could potentially save lives.
By Craig Boerner
February 13, 2019

Major initiative launched to advance the application of AI to health care

IBM Watson Health has announced plans to make a 10-year, $50 million investment in joint research collaborations with Brigham and Women’s Hospital — the teaching hospital of Harvard Medical School — and Vanderbilt University Medical Center to advance the science of artificial intelligence (AI) and its application to major public health issues.
By VUMC News and Communications
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