Proceedings of the National Academy of Sciences (PNAS) (journal)

August 3, 2017

HDAC3 role in B-cell development

The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

By Leigh MacMillan
July 20, 2017

Immune responses linked to cell’s recycling system

Autophagy is the cellular equivalent of trash pickup and recycling — it is a process by which proteins, protein aggregates and damaged cellular organelles are degraded in order to reuse nutrients and promote cellular metabolism.

By Bill Snyder
May 25, 2017

Study finds common brain scanning technique maps electrical activity as precisely as more invasive methods

A commonly used brain scanning technique can map electrical activity under the skull as precisely as more invasive methods that rely on probes or electrodes, researchers at Vanderbilt University Medical Center (VUMC) reported this month.

By Bill Snyder
April 14, 2017

A new mode of DNA repair

Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

By Leigh MacMillan
A large audience wearing 3D glasses in a darkened movie theater.
March 23, 2017

Study takes 3-D perspective on colorectal cancer

Despite dramatic recent advances in treatment, colorectal cancer killed more than 49,000 Americans last year, according to the National Cancer Institute, making it the second most lethal malignancy after cancers of the lung and bronchus.

By Bill Snyder
February 2, 2017

New target for chronic infection

An enzyme in macrophage immune cells may be a good target for treating chronic infections, Vanderbilt researchers have discovered.

By VUMC News and Communications
October 20, 2016

Research sheds light on how RSV wards off potential vaccines

Respiratory syncytial virus (RSV) is the major cause of life-threatening viral pneumonia in infants worldwide, yet despite repeated efforts, scientists have been unable to develop an effective vaccine against it.
By Bill Snyder
September 28, 2016

Targeting norovirus “noxiousness”

New discoveries will guide efforts to develop vaccines or antiviral agents for norovirus, the most common cause of infectious diarrhea.
By Bill Snyder
August 11, 2016

Team explores transcription factor’s autoimmunity role

Increasing expression of a transcription factor called KLF2 can promote immunological self-tolerance and “tune down” autoimmunity, researchers at Vanderbilt University Medical Center reported recently.
By Bill Snyder
June 2, 2016

VUMC researchers seek to crack the code of neonatal sepsis

Sepsis, an exaggerated and overwhelming inflammatory response to infection, is a major worldwide killer of babies in the first four weeks of life (neonatal period).
By Bill Snyder
May 13, 2016

New pain medicine from a fungus?

Collybolide – a natural product isolated from a mushroom – is a promising candidate for the development of non-addictive pain medicines.
By Sanjay Mishra
April 29, 2016

Improving natural killer cancer therapy

A newly discovered mechanism that helps cancer cells avoid destruction by immune system cells may improve immunotherapies.
By Sanjay Mishra
March 8, 2016

Fat hormone’s role in zebrafish

The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.
By Leigh MacMillan
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