Mass Spectrometry Research Center

Bacterial battle in 3D

Using imaging mass spectrometry and microscopy, Vanderbilt researchers visualized how staph bacteria modifies lipids in its membrane to evade immune system-mediated killing.

Imaging host-pathogen battle for metal

An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.

What protein is that?

An improved technology enables high-throughput protein identification in imaging mass spectrometry, aiding proteomics research.

New imaging approach offers unprecedented views of staph infection

A new integrated imaging approach makes it possible to probe the molecules involved in invasive infections and can be broadly applied to any health or disease state.

tug-of-rope pair

VUMC investigators find pathogens work together to infect host

Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection.

Richard Caprioli and mass spectrometer

NIH grant bolsters mass spectrometry research initiatives

The National Institutes of Health (NIH) has awarded a major renewal grant to continue the National Research Resource for Imaging Mass Spectrometry at Vanderbilt University School of Medicine.

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