Department of Cell and Developmental Biology

Microtubules are the “railroad tracks” essential for moving intracellular “freight” around in the cell. They’re also part of the spindle that pulls the two centrosomes apart during cell division.

Vanderbilt investigators have developed an algorithm to classify cell types from experimental data, making it possible to understand how organs develop.

Fifteen Vanderbilt faculty members conducting a range of biomedical and clinical research have been elected fellows of the American Association for the Advancement of Science. Six of the 15 have received funding through the university’s Trans-Institutional Programs initiative, which facilitates research and teaching collaborations across disciplines and are a core pillar of the university’s Academic Strategic Plan.

Lipids in the plasma membrane regulate the position of the contractile ring that is required for cell division, Vanderbilt researchers have discovered.

Using super-resolution microscopy tools in the Nikon Center of Excellence, Vanderbilt investigators have determined the molecular architecture of the contractile ring machinery that functions during cell division — a process that is essential for life.

Vanderbilt researchers have discovered that microvilli – finger-like projections from cells in the intestine – respond to the shear stress of fluid flow to drive a cellular pathway that regulates nutrient balance.

Vanderbilt investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings, reported this week in Nature Medicine, suggest a strategy for overcoming this resistance.